Finding the correct RE9 safe code can save you time, ammunition, and valuable resources in Resident Evil Requiem. The game places locked safes in important areas, and each one contains items that can help you survive difficult encounters. However, finding the right combination is not always easy, especially when enemies are nearby or you are trying to conserve supplies.
Resident Evil Requiem, commonly called Resident Evil 9 or RE9, continues the survival horror tradition of hiding useful items behind puzzles, locked containers, and clues scattered throughout the environment. Safes are an important part of this experience because they reward players who explore carefully and pay attention to their surroundings.
The good news is that you do not necessarily need to find every clue before opening a safe. Once you know the correct combination for your difficulty level, you can enter it directly.
In this guide, you will find all five RE9 safe codes, their locations, the rewards inside, and instructions for opening each one. You will also learn why certain combinations fail, how Insanity difficulty changes the answers, and which safes you should prioritize before progressing too far in the story.
Warning: This guide contains puzzle solutions and location spoilers. If you prefer discovering every combination yourself, read only the sections you need.
All RE9 Safe Codes at a Glance
Resident Evil Requiem features five locked safes with different combinations depending on the difficulty setting. Casual and Standard use the same combinations, while Insanity uses a separate set.
Here is a quick reference for every safe.
| Safe location | Casual/Standard code | Insanity code |
|---|---|---|
| Bar and Lounge | Left 10, Right 80, Left 30 | Right 20, Left 50, Right 30 |
| Examination Room | Right 30, Left 10, Right 50 | Left 50, Right 30, Left 90 |
| Basement Furnace | Right 60, Left 40, Right 80 | Left 70, Right 50, Left 20 |
| ARK Sterilization Chamber | Right 10, Left 90, Right 20 | Left 80, Right 50, Left 20 |
| ARK Monitor Control Room | Left 50, Right 60, Left 80 | Right 20, Left 0, Right 70 |
The direction is just as important as the number. Enter each turn in the listed order and use the correct direction for your difficulty.
1. Bar and Lounge Safe Code
The Bar and Lounge safe is one of the first locked containers you can encounter during Grace’s sections at the Care Center. It is worth opening because the contents provide useful resources for the challenges ahead.
Safe Combination
- Casual/Standard: Left 10 → Right 80 → Left 30
- Insanity: Right 20 → Left 50 → Right 30
Where Is the Bar and Lounge Safe?
Explore the Bar and Lounge area inside the Care Center. Look for the safe in the room and check your surroundings before interacting with it. If enemies are present, consider dealing with immediate threats before spending time on the combination.
If you cannot find the safe, check the room carefully rather than assuming it is hidden behind a separate puzzle.
What Is the Reward?
Opening this safe provides three Antique Coins. These coins are useful because they can be spent in the Parlor on available upgrades.
Antique Coins can be particularly valuable early in a playthrough, when improving your equipment or gaining useful benefits can make later encounters easier.
How to Open It
- Approach the safe and interact with the dial.
- Turn left until the dial reaches 10 on Casual or Standard.
- Turn right to 80.
- Turn left to 30.
- Confirm the combination to open the safe.
On Insanity, use Right 20, Left 50, and Right 30 instead.
Make sure you are using the correct difficulty combination before trying again.
2. Examination Room Safe Code
The Examination Room safe is another important discovery in the Care Center. Players often search for this combination because the reward can provide useful currency for upgrades.
Safe Combination
- Casual/Standard: Right 30 → Left 10 → Right 50
- Insanity: Left 50 → Right 30 → Left 90
Where Is the Examination Room Safe?
The safe is located inside the Examination Room in the East Wing of the Rhodes Hill Care Center.
As you explore this area, examine the available rooms and containers instead of rushing directly toward the next objective. The environment contains useful resources and clues that may help you understand other puzzles.
The combination clue can be found in a document elsewhere in the Care Center. However, you can use the correct combination without collecting that document first.
What Is Inside the Safe?
The Examination Room safe contains three Antique Coins.
These coins can be used in the Parlor, giving you another opportunity to obtain upgrades that support your progress through the game.
If you are collecting resources carefully, opening both the Bar and Lounge safe and the Examination Room safe can give you a useful early supply of coins.
Steps to Unlock the Safe
- Interact with the safe in the Examination Room.
- Turn right to 30.
- Turn left to 10.
- Turn right to 50.
- Confirm the combination.
For Insanity difficulty, enter Left 50, Right 30, and Left 90.
If the safe does not open, verify both the direction and the number of every turn. Entering the right numbers in the wrong order will not work.
3. Basement Furnace Safe Code
The Basement Furnace safe is particularly useful because its contents include ammunition and a map-related reward. These items can help you manage resources and explore the surrounding area more effectively.
Safe Combination
- Casual/Standard: Right 60 → Left 40 → Right 80
- Insanity: Left 70 → Right 50 → Left 20
Where Is the Basement Safe?
The safe is located in the Care Center Basement, near a forklift and a small shack. Look around the basement area carefully, especially if you are moving through it quickly during a story sequence.
This safe deserves attention because some opportunities to collect items can be missed when you progress too far.
During the relevant sections, pay attention to available paths, containers, and documents. If you intend to collect everything during one playthrough, avoid leaving an area before checking its important items.
What Rewards Can You Get?
The Basement Furnace safe contains a Raccoon Roundup map for the Rhodes Hill area and handgun ammunition.
The map can help with collectible hunting, while ammunition is useful for keeping your handgun ready for encounters.
In a survival horror game, ammunition is more than a simple reward. Every additional round may help you avoid spending other resources or dealing with an enemy using a less efficient approach.
How to Open the Basement Safe
- Reach the basement area and locate the safe.
- Interact with the dial.
- Turn right to 60.
- Turn left to 40.
- Turn right to 80.
- Confirm the combination and collect the rewards.
On Insanity difficulty, the correct sequence is Left 70, Right 50, and Left 20.
Important tip: Check the basement carefully before moving on. Missing a useful resource can make later sections more difficult, especially if you are playing with limited supplies.
4. ARK Sterilization Chamber Safe Code
The ARK section introduces another set of safe puzzles. By this stage, conserving ammunition and healing supplies becomes increasingly important, so opening available safes can provide a welcome advantage.
Safe Combination
- Casual/Standard: Right 10 → Left 90 → Right 20
- Insanity: Left 80 → Right 50 → Left 20
Where Is the Sterilization Chamber Safe?
The safe is located in the Sterilization Chamber inside the ARK facility.
Explore the area carefully and check nearby documents for clues. As with the other safes, the written clue can help you discover the answer naturally, but it is not required if you already know the correct combination.
Pay attention to nearby doors and the available paths. The ARK contains important late-game objectives, and some areas become inaccessible after certain story events.
What Is the Reward?
The safe contains:
- One Molotov.
- One Med Injector.
- Fifteen handgun rounds.
These items offer a useful combination of offensive and healing resources.
A Molotov can help against suitable groups or enemies, while a Med Injector provides a way to restore health. Handgun ammunition also gives you more flexibility when dealing with threats.
The exact usefulness of these items depends on your current inventory and the encounters ahead, but collecting them is generally worthwhile.
How to Unlock It
- Find the safe inside the Sterilization Chamber.
- Turn right to 10.
- Turn left to 90.
- Turn right to 20.
- Confirm the combination.
If you are playing on Insanity, enter Left 80, Right 50, and Left 20.
Before leaving the ARK area, make sure you have checked nearby rooms and collected any important resources you want to keep.
5. ARK Monitor Control Room Safe Code
The Monitor Control Room safe is the final safe in this guide and an important one to open if you want to complete the safe-related achievement.
Because it is located late in the game, it can be easy to overlook when you are focused on reaching the next objective.
Safe Combination
- Casual/Standard: Left 50 → Right 60 → Left 80
- Insanity: Right 20 → Left 0 → Right 70
Where Is the Monitor Control Room Safe?
The safe is located inside the Monitor Control Room in the ARK facility.
Look for the appropriate room while exploring the facility’s connected areas. Check the room before continuing through the final sequence, because progression can prevent you from returning to earlier locations.
If you are trying to complete all safe puzzles in one playthrough, this is an important opportunity to check your progress.
What Is Inside?
The Monitor Control Room safe contains:
- One Empty Bottle.
- One Bottle of Acid.
- One Med Injector.
These items provide additional crafting and healing resources. Their usefulness depends on your current supplies, but they can help you prepare for the remaining challenges.
How to Open the Monitor Control Room Safe
- Locate the safe in the Monitor Control Room.
- Turn left to 50.
- Turn right to 60.
- Turn left to 80.
- Confirm the combination and collect the contents.
For Insanity difficulty, enter Right 20, Left 0, and Right 70.
Remember that zero is an intentional part of the Insanity combination. Do not skip it or replace it with another number.
How the RE9 Safe Lock Mechanic Works
Resident Evil Requiem uses combination locks that require the correct numbers and directions in a particular sequence.
Unlike a simple keypad, where you enter a series of digits, these locks require you to turn the dial in the correct direction before moving to the next number.
For example, the Bar and Lounge combination on Standard difficulty is:
Left 10 → Right 80 → Left 30
This means you must reach 10 while turning left, reach 80 while turning right, and then reach 30 while turning left again.
The numbers alone are not enough. If you enter 10, 80, and 30 but use the wrong directions, the combination will fail.
What Do Left and Right Mean?
Follow the direction indicators shown by the game’s controls.
The left and right instructions refer to the direction in which you turn the safe’s dial, not the position of the safe or the direction in which your character is facing.
Pay attention to the game’s interface when entering the combination. This is especially important if you are switching between different games or using a controller layout that differs from what you normally use.
Do You Need to Find the Clue First?
No. You can generally open these safes using the correct combination without first collecting the document that reveals it.
However, finding the clue is still worthwhile if you enjoy solving puzzles naturally or want to understand how the game communicates its answers.
Documents can also help you recognize the intended solution rather than relying on an external guide.
Why Is My RE9 Safe Code Not Working?
If you have entered a combination and the safe remains locked, do not immediately assume the code is incorrect. Several common mistakes can cause the problem.
1. You Are Using the Wrong Difficulty Combination
The most important difference is between Standard or Casual and Insanity.
For example, the Basement Furnace safe uses Right 60, Left 40, Right 80 on Standard, but Left 70, Right 50, Left 20 on Insanity.
Solution: Confirm your current difficulty and use the matching combination.
2. You Entered the Numbers in the Wrong Order
Each safe requires a specific sequence.
Entering the same three numbers in a different order will not unlock it.
Solution: Read the full combination before turning the dial and complete the sequence from beginning to end.
3. You Turned the Dial in the Wrong Direction
Direction matters at every stage. A correct number reached using the wrong direction may not register as the required input.
Solution: Follow every left and right instruction exactly as written.
4. You Did Not Complete the Full Sequence
Some players try to confirm the combination after entering only one or two numbers.
Solution: Enter all three numbers and directions before confirming the lock.
5. You Are Looking at a Different Safe
The game contains multiple safes in separate locations. A combination intended for the Examination Room will not open the Bar and Lounge safe.
Solution: Match the safe’s location to the relevant section of this guide.
Tips for Finding Every Safe in One Playthrough
If you want to collect every safe reward, a little planning can make the process easier.
Explore Rooms Before Leaving
Before progressing through a major story sequence, inspect the current area for safes, documents, supplies, and other useful objects.
This is particularly important when a later event may prevent you from returning.
Keep Track of Opened Safes
- Use a simple checklist to monitor your progress.
- Bar and Lounge safe.
- Examination Room safe.
- Basement Furnace safe.
- ARK Sterilization Chamber safe.
ARK Monitor Control Room safe.
Once you have opened a safe, mark it as complete. This prevents unnecessary backtracking and helps you identify any remaining locations.
Save Before Major Progression Points
If you want to collect everything, consider keeping a manual save before important transitions when the game allows it.
This gives you a fallback if you realize you missed an item or safe that you cannot revisit later.
Collect Useful Resources Early
Ammunition, healing items, and upgrade currency can make a difference during difficult encounters. Although not every reward is equally important in every situation, opening a safe usually provides a useful opportunity to strengthen your inventory.
How to Unlock the No Safe Is Safe Achievement
Opening all five locked safes is associated with the No Safe Is Safe trophy or achievement.
To complete the requirement, make sure you have opened every safe covered in this guide:
- Bar and Lounge.
- Examination Room.
- Basement Furnace.
- ARK Sterilization Chamber.
- ARK Monitor Control Room.
Difficulty matters because the combinations change on Insanity, but the basic task remains the same: find each safe and enter its correct code.
If the achievement does not appear immediately, check your progress and confirm that all five safes were successfully opened.
Frequently Asked Questions
What Is the RE9 Safe Code?
There is no single combination for every safe in Resident Evil Requiem. The game has five locked safes, each with its own code. The correct combination also depends on whether you are playing on Casual, Standard, or Insanity difficulty.
Do RE9 Safe Codes Change Between Playthroughs?
The listed combinations are fixed for their respective difficulty settings rather than randomly generated for each playthrough. However, Insanity uses different combinations from Casual and Standard.
Can I Open a Safe Without Finding Its Clue?
Yes. You can use the correct combination directly without collecting the document that reveals it.
Which RE9 Safe Should I Open First?
Open each safe when you encounter it and have access to its location. The early Care Center safes provide Antique Coins, while the basement and ARK safes offer additional supplies and useful items.
Are the RE9 Safe Codes Different on Insanity?
Yes. Insanity uses a different combination for every safe listed in this guide. Always check the Insanity column if you are playing on that difficulty.
What Happens if I Enter the Wrong Code?
The safe will remain locked, and you will need to try again. Check the number sequence, direction, and difficulty setting before making another attempt.
How Many Locked Safes Are in Resident Evil Requiem?
There are five main locked safes covered by the standard safe-completion guide: two in the Care Center’s main areas, one in the basement, and two in the ARK facility. The game also contains other containers and puzzles, but they are not all combination safes.
Conclusion
Finding the correct RE9 safe code is an easy way to collect useful resources without spending too much time searching for every hidden clue. Resident Evil Requiem rewards exploration, and its safes offer Antique Coins, ammunition, healing supplies, and other items that can help you survive.
The most important thing to remember is that every safe has its own combination, and the directions matter just as much as the numbers. Casual and Standard share one set of codes, while Insanity requires different combinations.
Use the quick-reference table when you need an immediate answer, then check the individual sections for locations, rewards, and instructions. If you want to complete the No Safe Is Safe achievement, keep track of all five safes and open them before progressing beyond areas you may not be able to revisit.
With the correct combinations and a little preparation, you can unlock every safe more efficiently and focus on what matters most: surviving the dangers of Resident Evil Requiem.
